|
KMID : 1189220100370030231
|
|
Korean Journal of Reproductive Medicine
2010 Volume.37 No. 3 p.231 ~ p.237
|
|
|
Predominant T Helper 1 Immune Response in Women with Reproductive Failures
|
|
Yang Kwang-Moon
Han Ae-Ra
Kwak Kim Joanne
|
|
|
Abstract
|
|
|
Objective: To evaluate whether T helper 1 (Th1) immune response is predominant in women with reproductive failures (recurrent spontaneous abortion and recurrent implantation failure) and the activation of T cell is related to Th1 propensity.
Methods: Women with a history of recurrent implantation failure or recurrent spontaneous abortion comprise the study group (n=37). Controls are normal fertile women without a history of infertility or pregnancy losses (n=11). Th1/Th2 ratios of interferon (INF)-γ/interleukin (IL)-10 and tumor necrosis factor (TNF)-α/IL-10 expression on CD3+/4+ cells, CD154, and CD69 expression on T cells are measured by flow cytometric analysis.
Results: The ratios of TNF-α to IL-10 expressing on CD3+/4+ cells (Th1/Th2 cell ratios) are significantly higher in study group (42.1±2.3) as compared with that of controls (28.7±2.7) (p=0.002). The overall trend of CD154 and CD69 expression on T cells are elevated in study group than those of controls. The proportion (%) of CD3+/4+/154+ cells (1.7±0.5 vs. 0.3±0.2, p=0.038) and the % of CD3+/8+/154+ cells (0.6±0.2 vs. 0.1±0.0, p=0.024) are significantly higher in study group. The % of CD3+/69+ cells (5.6±1.9 vs. 1.3±5.4, p=0.046) and % of CD3+/8+/69+ cells (4.8±1.3 vs. 1.8±0.2, p=0.035) among CD3+/8+ cells are significantly increased in study group.
Conclusion: Women with reproductive failures have Th1 propensity with increased T cell activation. These finding means that activated T cell has a harmful effect on early pregnancy and implantation by induction of Th1 immunity.
|
|
|
KEYWORD
|
|
|
T cell activation, T helper 1 immunity, Reproductive fail
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|